Lê Thanh Vân (December 5, 1956 – October 26, 2005), known as The Cyanide Witch (Vietnamese: Phù Thủy Xyanua) was a Vietnamese fraudster and serial killer who, together with her husband and accomplice Dìu Dãnh Quang, poisoned at least 13 people with cyanide from 1998 to 2001 for financial gain. Regarded as the most prolific and infamous serial killer in the country's history, she was convicted, sentenced to death and subsequently executed for her crimes in 2005.

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